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Servicebio Inc tunel staining kit
Tunel Staining Kit, supplied by Servicebio Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/tunel+staining+kit/staining+tunel/pm42174638-76-1-12
Average 86 stars, based on 1 article reviews
tunel staining kit - by Bioz Stars, 2026-09
86/100 stars

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Related Articles

TUNEL Assay:

Article Title: Cannabidiol attenuates the LPS/D-Galactosamine-induced acute liver injury by inhibiting parkin-mediated ubiquitination of MFN2.
Article Snippet: Ethnopharmacological relevance: Acute liver injury (A-LI) is a clinical syndrome that can rapidly progress to acute liver failure, resulting in high mortality and poor prognosis.. Cannabis sativa L. is an important herbaceous plant that has been widely used in folk medicine since ancient times.. Cannabidiol (CBD) is its most abundant nonpsychoactive compound, exhibiting hepatoprotective, anti-inflammatory, and antioxidant properties.

Article Title: SLFN11 Enhances PARPi Sensitivity in Ovarian Cancer via Ubiquitin-Mediated Stabilization.
Article Snippet: Schlafen family member 11 (SLFN11), implicated in cancer drug resistance, may improve poly(ADP-ribose) polymerase inhibitor (PARPi) efficacy.. This study investigates SLFN11’s role in epithelial ovarian cancer (EOC) progression and its influence on PARPi sensitivity, particularly in BRCA-wild-type contexts, with a focus on its emerging function in proteostasis regulation.. SLFN11 expression in EOC and adjacent tissues was evaluated via immunohistochemistry, quantitative polymerase chain reaction (PCR), and Western blot.

Article Title: Ya Han Jie ameliorates adjuvant-induced arthritis by inhibiting the NF-κB/NETosis/inflammation axis.
Article Snippet: The H&E staining kit and a safranin O-fast green staining kit were purchased from Beijing Solarbio Science & Technology Co., Ltd. (Beijing, CHN). .. A TUNEL staining kit and a PAS staining kit were purchased from Servicebio (Wuhan, CHN). .. A toluidine blue staining kit was purchased from Beijing Leagene Biotechnology Co., Ltd. (Beijing, CHN).

Article Title: PAI-1 promotes thromboangiitis obliterans progression through NF-κB-NLRP3 pathway activation via HIF-1α-dependent signaling.
Article Snippet: Background: Thromboangiitis obliterans (TAO, Buerger's disease) is a chronic inflammatory disorder that affects small and medium-sized vessels in the limbs.. Although the pathogenesis of TAO remains incompletely understood, elevated levels of plasminogen activator inhibitor-1 (PAI-1) have been associated with cardiovascular diseases.. This study investigates the mechanism by which PAI-1 activates the NF-κB/NLRP3 inflammatory pathway in vascular endothelial cells through hypoxia-inducible factor-1α (HIF-1α), contributing to the pro-

Article Title: Berberine Alleviates Pancreatic β-Cell Ferroptosis and Injury in db/db Mice by Regulating the AGE/RAGE Pathway: Insight from Proteomic Analysis.
Article Snippet: Objective This study aimed to investigate the protective effects of berberine (BBR) on pancreatic β-cells and explore its underlying molecular mechanisms via a proteomics-based approach.. Methods Using db/db mice as a diabetes model, BBR was administered at doses of 100 mg/kg and 200 mg/kg for 8 weeks.. The protective effects were assessed through fasting blood glucose (FBG), oral glucose tolerance test (OGTT), insulin tolerance test (ITT), pancreatic histopathological analysis, and TUNEL staining.

Article Title: Exploring the EPO/EPOR-βCR/TLR9 pathways in sepsis-associated encephalopathy: Therapeutic implications of EPO and HBSP.
Article Snippet: Objective: Delirium is a prominent clinical manifestation of sepsis-associated encephalopathy (SAE) and is closely linked to increased mortality and adverse outcomes.. Erythropoietin (EPO), traditionally used for treating anemia, is increasingly recognized for its non-hematopoietic tissue-protective effects.. However, the relationship between EPO and the development of SAE, as well as the underlying mechanisms, remain unclear.

Article Title: Hydrogen regulates the aryl hydrocarbon receptor, improving bronchopulmonary dysplasia in neonatal rats and RLE-6TN cells exposed to hyperoxia
Article Snippet: .. TUNEL staining kit (GDP1042, Servicebio, China) was used to detect the number of cell death in lung tissue, and the experiment was performed according to the instructions of the kit. ..

Staining:

Article Title: Cannabidiol attenuates the LPS/D-Galactosamine-induced acute liver injury by inhibiting parkin-mediated ubiquitination of MFN2.
Article Snippet: Ethnopharmacological relevance: Acute liver injury (A-LI) is a clinical syndrome that can rapidly progress to acute liver failure, resulting in high mortality and poor prognosis.. Cannabis sativa L. is an important herbaceous plant that has been widely used in folk medicine since ancient times.. Cannabidiol (CBD) is its most abundant nonpsychoactive compound, exhibiting hepatoprotective, anti-inflammatory, and antioxidant properties.

Article Title: SLFN11 Enhances PARPi Sensitivity in Ovarian Cancer via Ubiquitin-Mediated Stabilization.
Article Snippet: Schlafen family member 11 (SLFN11), implicated in cancer drug resistance, may improve poly(ADP-ribose) polymerase inhibitor (PARPi) efficacy.. This study investigates SLFN11’s role in epithelial ovarian cancer (EOC) progression and its influence on PARPi sensitivity, particularly in BRCA-wild-type contexts, with a focus on its emerging function in proteostasis regulation.. SLFN11 expression in EOC and adjacent tissues was evaluated via immunohistochemistry, quantitative polymerase chain reaction (PCR), and Western blot.

Article Title: Ya Han Jie ameliorates adjuvant-induced arthritis by inhibiting the NF-κB/NETosis/inflammation axis.
Article Snippet: The H&E staining kit and a safranin O-fast green staining kit were purchased from Beijing Solarbio Science & Technology Co., Ltd. (Beijing, CHN). .. A TUNEL staining kit and a PAS staining kit were purchased from Servicebio (Wuhan, CHN). .. A toluidine blue staining kit was purchased from Beijing Leagene Biotechnology Co., Ltd. (Beijing, CHN).

Article Title: PAI-1 promotes thromboangiitis obliterans progression through NF-κB-NLRP3 pathway activation via HIF-1α-dependent signaling.
Article Snippet: Background: Thromboangiitis obliterans (TAO, Buerger's disease) is a chronic inflammatory disorder that affects small and medium-sized vessels in the limbs.. Although the pathogenesis of TAO remains incompletely understood, elevated levels of plasminogen activator inhibitor-1 (PAI-1) have been associated with cardiovascular diseases.. This study investigates the mechanism by which PAI-1 activates the NF-κB/NLRP3 inflammatory pathway in vascular endothelial cells through hypoxia-inducible factor-1α (HIF-1α), contributing to the pro-

Article Title: Berberine Alleviates Pancreatic β-Cell Ferroptosis and Injury in db/db Mice by Regulating the AGE/RAGE Pathway: Insight from Proteomic Analysis.
Article Snippet: Objective This study aimed to investigate the protective effects of berberine (BBR) on pancreatic β-cells and explore its underlying molecular mechanisms via a proteomics-based approach.. Methods Using db/db mice as a diabetes model, BBR was administered at doses of 100 mg/kg and 200 mg/kg for 8 weeks.. The protective effects were assessed through fasting blood glucose (FBG), oral glucose tolerance test (OGTT), insulin tolerance test (ITT), pancreatic histopathological analysis, and TUNEL staining.

Article Title: Exploring the EPO/EPOR-βCR/TLR9 pathways in sepsis-associated encephalopathy: Therapeutic implications of EPO and HBSP.
Article Snippet: Objective: Delirium is a prominent clinical manifestation of sepsis-associated encephalopathy (SAE) and is closely linked to increased mortality and adverse outcomes.. Erythropoietin (EPO), traditionally used for treating anemia, is increasingly recognized for its non-hematopoietic tissue-protective effects.. However, the relationship between EPO and the development of SAE, as well as the underlying mechanisms, remain unclear.

Article Title: Hydrogen regulates the aryl hydrocarbon receptor, improving bronchopulmonary dysplasia in neonatal rats and RLE-6TN cells exposed to hyperoxia
Article Snippet: .. TUNEL staining kit (GDP1042, Servicebio, China) was used to detect the number of cell death in lung tissue, and the experiment was performed according to the instructions of the kit. ..

Incubation:

Article Title: Exploring the EPO/EPOR-βCR/TLR9 pathways in sepsis-associated encephalopathy: Therapeutic implications of EPO and HBSP.
Article Snippet: Objective: Delirium is a prominent clinical manifestation of sepsis-associated encephalopathy (SAE) and is closely linked to increased mortality and adverse outcomes.. Erythropoietin (EPO), traditionally used for treating anemia, is increasingly recognized for its non-hematopoietic tissue-protective effects.. However, the relationship between EPO and the development of SAE, as well as the underlying mechanisms, remain unclear.



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Co-administration of C. chinensis and B. breve S1 improved the pathological manifestations of AD mice. (A) Construction of B. breve S1 AD mice (* P < 0.05 ** P < 0.01 *** P < 0.001 vs D1, # P < 0.05 ## P < 0.01 ### P < 0.001 vs D7). (B) Statistical chart of latency time of Barnes maze test in AD mice ( n = 5). (C) Statistical chart of target quadrant ratio of Barnes maze test in mice ( n = 5). (D) Statistical chart of total displacement of Barnes maze test in mice ( n = 5). (E) The content of A β in serum ( n = 5). (F) The content of A β in brain ( n = 5). n. s., no significant difference, # P < 0.05 ### P < 0.001 vs Control group, * P < 0.05 ** P < 0.01 *** P < 0.001 vs Model-free group, n.s. not significant. (G) Results of Congo <t>red</t> <t>staining</t> (arrow: amyloid protein deposition, n = 5, scale bar: 500 μm, × 40). (H) Results of HE staining ( n = 5, scale bar: 50 μm, × 400). (I) Results of <t>TUNEL</t> staining (arrow: apoptotic cells, n = 5, scale bar: 50 μm, × 400).
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OM-MSCs-Exo alleviated cognitive impairment and neuroinflammation in AD mice through FGFR1. A Swimming distance, swimming time, number of platform arrivals, and latency to first entry ( n = 6). B The hippocampal tissues of mice were stained with HE. C Nissl staining was performed in the hippocampus of mice. D <t>TUNEL</t> assay. E Data plot of the TUNEL assay. F Levels of IL-1β, TNF-α, and IL-6 in mice hippocampus. G WB analysis of Aβ, p-Tau/Tau in mice hippocampus. H Aβ 1–42 levels were detected. I FGFR1 and PLCγ1 levels were measured. J Levels of p-NF-κB/NF-κB. K , L IF staining of CD86 and CD206 in mice hippocampus. M Levels of microglia M1 and M2 polarization–related factors in mice hippocampus ( n = 5). * p < 0.05, ** p < 0.01, *** p < 0.001. Normality was confirmed using the Shapiro–Wilk test. Thereafter, data were analyzed with a one-way ANOVA (followed by Tukey’s post hoc test) for multiple-group comparisons
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Image Search Results


Co-administration of C. chinensis and B. breve S1 improved the pathological manifestations of AD mice. (A) Construction of B. breve S1 AD mice (* P < 0.05 ** P < 0.01 *** P < 0.001 vs D1, # P < 0.05 ## P < 0.01 ### P < 0.001 vs D7). (B) Statistical chart of latency time of Barnes maze test in AD mice ( n = 5). (C) Statistical chart of target quadrant ratio of Barnes maze test in mice ( n = 5). (D) Statistical chart of total displacement of Barnes maze test in mice ( n = 5). (E) The content of A β in serum ( n = 5). (F) The content of A β in brain ( n = 5). n. s., no significant difference, # P < 0.05 ### P < 0.001 vs Control group, * P < 0.05 ** P < 0.01 *** P < 0.001 vs Model-free group, n.s. not significant. (G) Results of Congo red staining (arrow: amyloid protein deposition, n = 5, scale bar: 500 μm, × 40). (H) Results of HE staining ( n = 5, scale bar: 50 μm, × 400). (I) Results of TUNEL staining (arrow: apoptotic cells, n = 5, scale bar: 50 μm, × 400).

Journal: Chinese Herbal Medicines

Article Title: Isoquinoline alkaloids in Coptis chinensis to treat Alzheimer’s disease through promoting growth of Bifidobacterium breve inhibiting abnormal autophagy using a novel AI high-content intelligent imaging system

doi: 10.1016/j.chmed.2026.02.003

Figure Lengend Snippet: Co-administration of C. chinensis and B. breve S1 improved the pathological manifestations of AD mice. (A) Construction of B. breve S1 AD mice (* P < 0.05 ** P < 0.01 *** P < 0.001 vs D1, # P < 0.05 ## P < 0.01 ### P < 0.001 vs D7). (B) Statistical chart of latency time of Barnes maze test in AD mice ( n = 5). (C) Statistical chart of target quadrant ratio of Barnes maze test in mice ( n = 5). (D) Statistical chart of total displacement of Barnes maze test in mice ( n = 5). (E) The content of A β in serum ( n = 5). (F) The content of A β in brain ( n = 5). n. s., no significant difference, # P < 0.05 ### P < 0.001 vs Control group, * P < 0.05 ** P < 0.01 *** P < 0.001 vs Model-free group, n.s. not significant. (G) Results of Congo red staining (arrow: amyloid protein deposition, n = 5, scale bar: 500 μm, × 40). (H) Results of HE staining ( n = 5, scale bar: 50 μm, × 400). (I) Results of TUNEL staining (arrow: apoptotic cells, n = 5, scale bar: 50 μm, × 400).

Article Snippet: TUNEL staining kit (lot number: 01981015) was purchased from Shanghai Epizyme Biomedical Technology Co., Ltd. (Shanghai, China).

Techniques: Control, Staining, TUNEL Assay

OM-MSCs-Exo alleviated cognitive impairment and neuroinflammation in AD mice through FGFR1. A Swimming distance, swimming time, number of platform arrivals, and latency to first entry ( n = 6). B The hippocampal tissues of mice were stained with HE. C Nissl staining was performed in the hippocampus of mice. D TUNEL assay. E Data plot of the TUNEL assay. F Levels of IL-1β, TNF-α, and IL-6 in mice hippocampus. G WB analysis of Aβ, p-Tau/Tau in mice hippocampus. H Aβ 1–42 levels were detected. I FGFR1 and PLCγ1 levels were measured. J Levels of p-NF-κB/NF-κB. K , L IF staining of CD86 and CD206 in mice hippocampus. M Levels of microglia M1 and M2 polarization–related factors in mice hippocampus ( n = 5). * p < 0.05, ** p < 0.01, *** p < 0.001. Normality was confirmed using the Shapiro–Wilk test. Thereafter, data were analyzed with a one-way ANOVA (followed by Tukey’s post hoc test) for multiple-group comparisons

Journal: Molecular Neurobiology

Article Title: Olfactory Mucosa Mesenchymal Stem Cell–Derived Exosomes Enhance Microglia M2 Polarization via the FGFR1/PLCγ1 Axis to Alleviate Alzheimer’s Disease

doi: 10.1007/s12035-026-05797-w

Figure Lengend Snippet: OM-MSCs-Exo alleviated cognitive impairment and neuroinflammation in AD mice through FGFR1. A Swimming distance, swimming time, number of platform arrivals, and latency to first entry ( n = 6). B The hippocampal tissues of mice were stained with HE. C Nissl staining was performed in the hippocampus of mice. D TUNEL assay. E Data plot of the TUNEL assay. F Levels of IL-1β, TNF-α, and IL-6 in mice hippocampus. G WB analysis of Aβ, p-Tau/Tau in mice hippocampus. H Aβ 1–42 levels were detected. I FGFR1 and PLCγ1 levels were measured. J Levels of p-NF-κB/NF-κB. K , L IF staining of CD86 and CD206 in mice hippocampus. M Levels of microglia M1 and M2 polarization–related factors in mice hippocampus ( n = 5). * p < 0.05, ** p < 0.01, *** p < 0.001. Normality was confirmed using the Shapiro–Wilk test. Thereafter, data were analyzed with a one-way ANOVA (followed by Tukey’s post hoc test) for multiple-group comparisons

Article Snippet: According to the manufacturer’s instructions, sections were stained with a TdT-mediated dUTP nick-end labeling (TUNEL) staining kit (40306ES50; YEASEN) and a DAPI working solution under dark conditions.

Techniques: Staining, TUNEL Assay